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Bioinformatics Advance Access published online on August 30, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti651
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© The Author (2005). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received June 6, 2005
Revised August 25, 2005
Accepted August 26, 2005

Discovery note

Negative correlation between compositional symmetries and local recombination rates

Liang Chen 1 and Hongyu Zhao 2*

1 Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA
2 Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut, USA; Department of Genetics, Yale University, New Haven, Connecticut, USA

* To whom correspondence should be addressed.
Hongyu Zhao, E-mail: hongyu.zhao{at}yale.edu


  Abstract

Although still not much understood, the universal reverse complement symmetry in genomes may contain much information about the genome. In this article, under the hypothesis that recombination rate variations may be related to the high order DNA structure, we studied the association between local recombination rates and local symmetry levels in mouse, rat, and human. We found significant negative correlations between recombination rates and reverse complement compositional symmetries in these three organisms. This negative correlation pattern also held at individual chromosome levels when data only from each individual chromosome was analyzed.


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