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Bioinformatics Advance Access published online on September 27, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti689
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© The Author (2005). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received August 1, 2005
Revised September 21, 2005
Accepted September 22, 2005

Applications note

HapSim: a simulation tool for generating haplotype data with pre-specified allele frequencies and LD coefficients

Giovanni Montana 1*

1 Department of Mathematics, Imperial College London

* To whom correspondence should be addressed.
Giovanni Montana, E-mail: g.montana{at}imperial.ac.uk


  Abstract

We have developed a simulation tool HapSim for the generation of haplotype data. The simulated haplotypes are such that their allele frequencies and linkage disequilibrium coefficients match exactly those estimated in a real sample.

Availability: The program is available as an R package and can be downloaded from http://cran.r-project.org/.


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