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Bioinformatics Advance Access published online on September 27, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti693
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© The Author (2005). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received July 21, 2005
Revised September 22, 2005
Accepted September 23, 2005

Applications note

MACiE: a database of enzyme reaction mechanisms

Gemma L. Holliday 1, Gail J. Bartlett 2, Daniel E. Almonacid 1, Noel M. O'Boyle 1, Peter Murray-Rust 1, Janet M. Thornton 3, and John B. O. Mitchell 1*

1 Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
2 EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK; Current Address: Bioinformatics Support Service (Biochemistry Building), Centre for Bioinformatics, Division of Molecular Biosciences, Faculty of Life Sciences, Imperial College London, London, SW7 2AZ, UK
3 EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK

* To whom correspondence should be addressed.
John B. O. Mitchell, E-mail: jbom1{at}cam.ac.uk


  Abstract

Summary: MACiE (Mechanism, Annotation and Classification in Enzymes) is a publicly available web-based database, held in CMLReact (an XML application), that aims to help our understanding of the evolution of enzyme catalytic mechanisms and also to create a classification system which reflects the actual chemical mechanism (catalytic steps) of an enzyme reaction, not only the overall reaction.

Availability: http://www-mitchell.ch.cam.ac.uk/macie/.


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