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Bioinformatics Advance Access published online on October 10, 2005
Bioinformatics, doi:10.1093/bioinformatics/bti704
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© The Author (2005). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received June 5, 2005
Revised September 15, 2005
Accepted October 3, 2005

Applications note

ATID: a web-oriented database for collection of publicly available alternative translational initiation events

Jun Cai 1* +, Jing Zhang 1 +, Ying Huang 2, and Yanda Li 1

1 MOE Key Laboratory of Bioinformatics and Department of Automation, Tsinghua University, Beijing, 100084, China
2 MOE Key Laboratory of Bioinformatics and Department of Automation, Tsinghua University, Beijing, 100084, China; Current address: Center of Excellence in Bioinformatics, University at Buffalo, 901 Washington Street, Buffalo, NY 14203, USA

* To whom correspondence should be addressed.
Jun Cai, E-mail: caijun99{at}mails.tsinghua.edu.cn


  Abstract

Summary: Alternative translational initiation is an important cellular mechanism contributing to the diversity of protein products and functions. We develop a database that provides a comprehensive collection of alternative translational initiation events. The purpose of this alternative translational initiation database (ATID) is to facilitate the systematic study of alternative translational initiation of genes. The current version of database contains 300 genes from Homo sapiens, Mus musculus and other species. Each of the genes has two or more isoforms due to alternative translational initiation. Resources in ATID, including gene information, alternative products of genes, and domain structures of isoforms, are provided through a user-friendly web-interface.

Availability: The ATID database is available for public use at http://bioinfo.au.tsinghua.edu.cn/atie/. Supplementary instructions about this database and further statistical analyses can also be found on the webpage.

+ These two authors contributed equally to this work and should be regarded as joint first authors.
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