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Bioinformatics Advance Access published online on December 20, 2005
Bioinformatics, doi:10.1093/bioinformatics/btk009
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© The Author (2005). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received December 5, 2005
Accepted December 13, 2005

Article

MiGenes: a searchable interspecies database of mitochondrial proteins curated using Gene Ontology annotation

Siddhartha Basu 1, Erich Bremer 1, Chun Zhou 1, and Daniel F. Bogenhagen 1 *

1 Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794-8651

* To whom correspondence should be addressed.
Daniel F. Bogenhagen, E-mail: dan{at}pharm.sunysb.edu


  Abstract

Motivation: There has been an explosion of interest in the role of mitochondria in programmed cell death and other fundamental pathological processes underlying the development of human diseases. Nevertheless, the inventory of mitochondrial proteins encoded in the nuclear genome remains incomplete, providing an impediment to mitochondrial research at the interface with systems biology. We created the MiGenes database to further define the scope of the mitochondrial proteome in humans and model organisms including mice, rats, flies and worms as well as budding and fission yeasts. MiGenes is intended to stimulate mitochondrial research using model organisms.

Summary: MiGenes is a large-scale relational database that is automatically updated to keep pace with advances in mitochondrial proteomics and is curated to assure that the designation of proteins as mitochondrial reflects gene ontology annotations supported by high-quality evidence codes. A set of postulates is proposed to help define which proteins are authentic components of mitochondria. MiGenes incorporates over 1160 new gene ontology (GO) annotations to human, mouse and rat protein records, 370 of which represent the first GO annotation reflecting a mitochondrial localization. MiGenes employs a flexible search interface that permits batchwise accession number searches to support high-throughput proteomic studies. A web interface is provided to permit members of the mitochondrial research community to suggest modifications in protein annotations or mitochondrial status.

Availability: MiGenes is available at http://www.pharm.stonybrook.edu/migenes.


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