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Bioinformatics Advance Access published online on January 19, 2006
Bioinformatics, doi:10.1093/bioinformatics/btk031
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© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received October 26, 2005
Revised December 12, 2005
Accepted December 28, 2005

Applications note

SUSPECTS: enabling fast and effective prioritization of positional candidates

E. A. Adie 1 *, R. R. Adams 1, K. L. Evans 1, D. J. Porteous 1, and B. S. Pickard 1

1 Medical Genetics Section, School of Molecular and Clinical Medicine, University of Edinburgh EH4 2XU, UK

* To whom correspondence should be addressed.
E. A. Adie, E-mail: euan.adie{at}ed.ac.uk


  Abstract

Summary: SUSPECTS is a web-based server which combines annotation and sequence based approaches to prioritize disease candidate genes in large regions of interest. It uses multiple lines of evidence to rank genes quickly and effectively while limiting the effect of annotation bias to significantly improve performance.

Availability: SUSPECTS is freely available at http://www.genetics.med.ed.ac.uk/suspects/.

Supplementary Information: A quick-start guide in Macromedia Flash format is available at http://www.genetics.med.ed.ac.uk/suspects/help.shtml. Excel spreadsheets detailing the comparative performance of the software are included as supplementary material.

Associate Editor: Satoru Miyano
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