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Bioinformatics Advance Access published online on January 10, 2006
Bioinformatics, doi:10.1093/bioinformatics/btk043
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© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received December 11, 2005
Revised January 4, 2006
Accepted January 4, 2006

Discovery note

Haloferax volcanii PitA: an example of functional interaction between the Pfam chlorite dismutase and antibiotic biosynthesis monooxygenase families?

Elizabeta Bab-Dinitz 1, Hagay Shmuely 1, Julie Maupin-Furlow 2, Jerry Eichler 1, and Boaz Shaanan 1 *

1 Department of Life Sciences, Ben Gurion University, Beersheva 84105, Israel
2 Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611-0700, USA

* To whom correspondence should be addressed.
Boaz Shaanan, E-mail: bshaanan{at}bgu.ac.il


  Abstract

A curious fusion between chlorite dismutase- and antibiotic biosynthesis monooxygenase-like domains within a single open reading frame has been revealed by both sequence homology and structural modeling in Haloferax volcanii PitA and its homologues in other halophilic archaea. While this fusion may reflect an environmental adaptation to life in hypersaline environments and hence one specific to haloarchaea, PitA and its homologues may represent a paradigm for biologically-relevant interplay between these two distinct activities in accordance with the Rosetta Stone approach.

Associate Editor: Chris Stoeckert
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