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Bioinformatics Advance Access published online on January 28, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl026
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© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received September 12, 2005
Revised January 24, 2006
Accepted January 24, 2006

Article

siRecords: an extensive database of mammalian siRNAs with efficacy ratings

Yongliang Ren 1 1, Wuming Gong 1 1, Qiqi Xu 2, Xin Zheng Dong Lin 2, Yejun Wang 2, and Tongbin Li 2 *

1 Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455;
2 Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455

* To whom correspondence should be addressed.
Tongbin Li, E-mail: toli{at}biocompute.umn.edu.


  Abstract

Summary: Short interfering RNAs have been gaining popularity as the gene knock-down tool of choice by many researchers due to the clean nature of their workings as well as the technical simplicity and cost efficiency in their applications. We have constructed siRecords, a database of siRNAs experimentally tested by researchers with consistent efficacy ratings. This database will help siRNA researchers develop more reliable siRNA design rules; in the mean time, benefit experimental researchers directly by providing them with information about the siRNAs that have been experimentally tested against the genes of their interest. Currently, more than 4,100 carefully annotated siRNA sequences obtained from more than 1,200 published siRNA studies are hosted in siRecords. This database will continue to expand as more experimentally tested siRNAs are published.

Availability: The siRecords database can be accessed at http://siRecords.umn.edu/siRecords/.

1These authors contributed equally to this work
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