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Bioinformatics Advance Access published online on March 1, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl072
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© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received December 16, 2005
Revised February 8, 2006
Accepted February 23, 2006

Applications note

PIANA: protein interactions and network analysis

Ramon Aragues 1, Daniel Jaeggi 1, and Baldo Oliva 1 *

1 Structural Bioinformatics Group (GRIB-IMIM), Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Catalonia (Spain)

* To whom correspondence should be addressed.
Baldo Oliva, E-mail: boliva{at}imim.es


  Abstract

Summary: We present a software framework and tool called PIANA that facilitates working with protein interaction networks by 1) integrating data from multiple sources, 2) providing a library that handles graph-related tasks and 3) automating the analysis of protein-protein interaction networks. PIANA can also be used as a stand-alone application to create protein interaction networks and perform tasks such as predicting protein interactions and helping to identify spots in a 2D electrophoresis gel.

Availability: PIANA is under the GNU GPL. Source code, database and detailed documentation may be freely downloaded from http://sbi.imim.es/piana.

Associate Editor: Jonathan Wren
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