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Bioinformatics Advance Access published online on March 1, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl073
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© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received November 30, 2005
Revised January 26, 2006
Accepted February 23, 2006

Article

Family specific rates of protein evolution

Hannes Luz 1 * and Martin Vingron 1

1 Max Planck Institute for Molecular Genetics, Ihnestr. 73, 14195 Berlin, Germany

* To whom correspondence should be addressed.
Hannes Luz, E-mail: luz{at}molgen.mpg.de


  Abstract

Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework and spot sets of slowly and fast evolving proteins.

Results: We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.

Supplementary information: http://speeds.molgen.mpg.de.

Associate Editor: Thomas Lengauer
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