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Bioinformatics Advance Access published online on April 13, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl143
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© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received March 6, 2006
Revised March 28, 2006
Accepted April 10, 2006

Applications note

FlyTF: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster

Boris Adryan 1 * and Sarah A. Teichmann 1

1 MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom

* To whom correspondence should be addressed.
Boris Adryan, E-mail: boris{at}mrc-lmb.cam.ac.uk


  Abstract

Summary: We present a manually annotated catalogue of site-specific transcription factors in the fruit fly Drosophila melanogaster. These were identified from a list of candidate proteins with transcription-related Gene Ontology annotation as well as structural DNA binding domain assignments. For all 1052 candidate proteins, a defined set of rules was applied to classify information from the literature and computational data sources with respect to both DNA binding and transcriptional regulatory properties. We propose a set of 753 transcription factors in the fruit fly, of which 23 are confident novel predictions of this function for previously uncharacterized proteins.

Availability: http://www.flytf.org/ (includes Supplementary Material).

Associate Editor: Alex Bateman
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