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Bioinformatics Advance Access published online on April 27, 2006

Bioinformatics, doi:10.1093/bioinformatics/btl159
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© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received February 3, 2006
Revised March 21, 2006
Accepted April 21, 2006

Applications note

An online literature mining tool for protein phosphorylation

X. Yuan 1 *, Z. Z. Hu 1 * *, H. T. Wu 1, M. Torii 2, M. Narayanaswamy 3, K. E. Ravikumar 3, K. Vijay-Shanker 2, and C. H. Wu 1

1 Protein Information Resource, Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC 20007, USA
2 Department of Computer and Information Sciences, University of Delaware, Newark, DE 19716, USA
3 AU-KBC Research Centre, Anna University, Chennai, India

* To whom correspondence should be addressed.
Z. Z. Hu, E-mail: zh9{at}georgetown.edu


   Abstract

A web-based version of the RLIMS-P literature mining system was developed for online mining of protein phosphorylation information from MEDLINE abstracts. The online tool presents extracted phosphorylation objects (phosphorylated proteins, phosphorylation sites, and protein kinases) in summary tables and full reports with evidence-tagged abstracts. The tool further allows mapping of phosphorylated proteins to protein entries in the UniProt Knowledgebase based on PubMed ID and/or protein name. The literature mining, coupled with database association, allows retrieval of rich biological information for the phosphorylated proteins and facilitates database annotation of phosphorylation features.

Availability: The online RLIMS-P is freely accessible at http://pir.georgetown.edu/iprolink/rlimsp.

Supplementary Data: http://pir.georgetown.edu/iprolink/rlimsp/supplement/.


Associate Editor: Thomas Lengauer

*The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors


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