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Bioinformatics Advance Access published online on May 16, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl188
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© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received March 20, 2006
Revised May 10, 2006
Accepted May 11, 2006

Applications note

FCP: functional coverage of the proteome by structures

Ricard García-Serna 1, Lulla Opatowski 1, and Jordi Mestres 1 *

1 Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Institut Municipal d'Investigació Mèdica and Universitat Pompeu Fabra, Dr Aiguader 88, 08003 Barcelona, Catalonia, Spain

* To whom correspondence should be addressed.
Jordi Mestres, E-mail: jmestres{at}imim.es


  Abstract

Motivation: Tools and resources for translating the remarkable growth witnessed in recent years in the number of protein structures determined experimentally into actual gain in the functional coverage of the proteome are increasingly necessary. We introduce FCP, a publicly accessible web tool dedicated to analyzing the current state and trends of the population of structures within protein families. FCP offers both graphical and quantitative data on the degree of functional coverage of enzymes and nuclear receptors by existing structures, as well as on the bias observed in the distribution of structures along their respective functional classification schemes.

Availability: http://cgl.imim.es/fcp/.

Associate Editor: Martin Bishop
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