Bioinformatics Advance Access published online on May 23, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl268
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1 Catalan Institute of Oncology, IDIBELL, Epidemiology and Cancer Registry, L'Hospitalet, Barcelona, Spain
* To whom correspondence should be addressed.
Summary: A web-based application has been designed from a genetic-epidemiology point of view to analyze association studies. Main capabilities include: descriptive analysis, test for Hardy-Weinberg equilibrium and linkage disequilibrium. Analysis of association is based on linear or logistic regression according to the response variable (quantitative or binary disease status respectively). Analysis of single SNPs: multiple inheritance models (co-dominant, dominant, recessive, over-dominant and log-additive), and analysis of interactions (gene-gene or gene-environment). Analysis of multiple SNPs: haplotype frequency estimation, analysis of association of haplotypes with the response, including analysis of interactions. Availability: Main page: http://bioinfo.iconcologia.net/SNPstats. Source code for local installation is available under GNU license. Supplementary information: Figures with a sample run are available on Bioinformatics online. A detailed online tutorial is available within the application.
Received March 6, 2006
Revised May 16, 2006
Accepted May 18, 2006
Applications note
SNPStats: a web tool for the analysis of association studies
Xavier Solé 1,
Elisabet Guinó 1,
Joan Valls 2,
Raquel Iniesta 1,
and
Víctor Moreno 2 *
2 Catalan Institute of Oncology, IDIBELL, Epidemiology and Cancer Registry, L'Hospitalet, Barcelona, Spain; Autonomous University of Barcelona, Laboratory of Biostatistics and Epidemiology, Bellaterra, Barcelona, Spain
Víctor Moreno, E-mail: v.moreno{at}iconcologia.net
Abstract
Associate Editor: Charlie Hodgman
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