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Bioinformatics Advance Access published online on June 29, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl340
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© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received April 4, 2006
Revised June 1, 2006
Accepted June 20, 2006

Discovery note

Eicosapentapeptide repeats (EPRs): novel repeat proteins specific to flowering plants

Sunil Archak 1 and Javaregowda Nagaraju 1 *

1 Laboratory of Molecular Genetics, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India

* To whom correspondence should be addressed.
Javaregowda Nagaraju, E-mail: jnagaraju{at}cdfd.org.in


  Abstract

In this report, we describe a novel tandem peptide repeat protein, EPR, which occurs notably only in flowering plants. The EPRs are characterised by a 25-amino acid repeat unit, X2CX4CX10CX2HGGG, repeated ten times tandemly. Sequence search revealed that the repeat motif is highly conserved across its occurrence. EPRs are predicted to exist as quasi-globular stable structures owing to highly conserved amino acid positions and potential disulfide bridges. Proteins containing EPRs are predicted to be located in chloroplasts; non-enzymatic and peptide or DNA binding in molecular function; and possibly involved in transcription regulation.

Supplementary information: Architecture, identifiers and annotations of EPRs; search parameters, distribution and sequence alignment; 2D structure prediction and disulfide connectivity are provided as pdf files S1-S8.

Associate Editor: Dmitrij Frishman
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