Skip Navigation



Bioinformatics Advance Access published online on June 29, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl347
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
22/17/2173    most recent
btl347v1
Right arrow Comments: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Comments are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Bush, W. S.
Right arrow Articles by Ritchie, M. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bush, W. S.
Right arrow Articles by Ritchie, M. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received February 11, 2006
Revised June 12, 2006
Accepted June 22, 2006

Applications note

Parallel multifactor dimensionality reduction: a tool for the large scale analysis of gene-gene interactions

William S. Bush 1, Scott M. Dudek 1, and Marylyn D. Ritchie 1 *

1 Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee

* To whom correspondence should be addressed.
Marylyn D. Ritchie, E-mail: ritchie{at}chgr.mc.vanderbilt.edu


  Abstract

Summary: Parallel multifactor dimensionality reduction is a tool for large scale analysis of gene-gene and gene-environment interactions. The MDR algorithm was redesigned to allow an unlimited number of study subjects, total variables, and variable states, and to remove restrictions on the order of interactions being analyzed. In addition, the algorithm is markedly more efficient, with an approximately 150-fold decrease in runtime for equivalent analyses. To facilitate the processing of large datasets, the algorithm was made parallel.

Availability: Parallel MDR is freely available for non-commercial research institutions. For full details see http://chgr.mc.vanderbilt.edu/ritchielab/pMDR. An open-source version of MDR software is available at http://www.epistasis.org.

Associate Editor: Martin Bishop
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
D. S. Postma and G. H. Koppelman
Genetics of Asthma: Where Are We and Where Do We Go?
Proceedings of the ATS, May 1, 2009; 6(3): 283 - 287.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
P. Chanda, L. Sucheston, A. Zhang, D. Brazeau, J. L. Freudenheim, C. Ambrosone, and M. Ramanathan
AMBIENCE: A Novel Approach and Efficient Algorithm for Identifying Informative Genetic and Environmental Associations With Complex Phenotypes
Genetics, October 1, 2008; 180(2): 1191 - 1210.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.