Skip Navigation



Bioinformatics Advance Access published online on October 10, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl450
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
22/21/2643    most recent
btl450v1
Right arrow Comments: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Comments are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Rajicic, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rajicic, N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received May 11, 2006
Revised August 15, 2006
Accepted August 17, 2006

Article

Survival analysis of longitudinal microarrays

Natasa Rajicic 1, Dianne M. Finkelstein 1 *, and David A. Schoenfeld 1, the Inflammation and Host Response to Injury Research Program Investigators *

1 Massachusetts General Hospital, Biostatistics Unit, 50 Staniford St, Suite 560, Boston, MA; Department of Biostatistics, Harvard School of Public Health, Boston, MA

* To whom correspondence should be addressed.
Dianne M. Finkelstein, E-mail: dfinkelstein{at}partners.org


  Abstract

Motivation: The development of methods for linking gene expressions to various clinical and phenotypic characteristics is an active area of genomic research. Scientists hope that such analysis may, for example, describe relationships between gene function and clinical events such as death or recovery. Methods are available for relating gene expression to measurements that are categorized or continuous, but there is less work in relating expressions to an observed event time such as time to death, response, or relapse. When gene expressions are measured over time, there are methods for differentiating temporal patterns. However, no methods have yet been proposed for the survival analysis of longitudinally collected microarrays.

Results: We describe an approach for the survival analysis of longitudinal gene expression data. We construct a measure of association between the time to an event and gene expressions collected over time. Statistical significance is addressed using permutations and control of the false discovery rate. Our proposed method is illustrated on a data set from a multi-center research study of inflammation and response to injury that aims to uncover the biological reasons why patients can have dramatically different outcomes after suffering a traumatic injury (www.gluegrant.org).

Associate Editor: Martin Bishop

*Contributing members of the Inflammation and the Host Response to Injury investigators are listed in Acknowledgments.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.