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Bioinformatics Advance Access published online on September 11, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl466
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© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received July 26, 2006
Revised August 25, 2006
Accepted August 28, 2006

Applications note

Augur - a computational pipeline for whole genome microbial surface protein prediction and classification

A. Billion 1 *, R. Ghai 1, T. Chakraborty 1, and T. Hain 1

1 Institute of Medical Microbiology, Justus-Liebig-University, Frankfurter Strasse 107, D-35392 Giessen, Germany

* To whom correspondence should be addressed.
A. Billion, E-mail: Andre.Billion{at}mikrobio.med.uni-giessen.de


  Abstract

Summary: The analysis of protein function is a challenge and a major bottleneck towards well-annotated and analysed microbial genomes. In particular, bacterial surface proteins present an opportunity for pharmacological intervention and vaccine development. We present Augur, an automatic prediction pipeline that integrates major surface prediction algorithms and enables comparative analysis, classification and visualization for gram-positive bacteria on a genomic scale.

Availability: http://bioinfo.mikrobio.med.uni-giessen.de/augur.

Associate Editor: Alfonso Valencia
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