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Bioinformatics Advance Access published online on September 5, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl468
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© 2006 The Author(s)
Received June 14, 2006
Revised August 7, 2006
Accepted August 29, 2006

Discovery note

DUF283 domain of Dicer proteins has a double-stranded RNA-binding fold

Mensur Dlakic 1 *

1 Department of Microbiology, Montana State University, Bozeman, MT 59717-3520 USA

* To whom correspondence should be addressed.
Mensur Dlakic, E-mail: mdlakic{at}montana.edu


  Abstract

Two RNases, Dicer and Argonaute, are at the heart of the RNA interference (RNAi) molecular machinery responsible for gene silencing. Both RNases contain multiple domains, most of which have been characterized or have functions that can be predicted based on sequence comparisons. However, Dicers of higher eukaryotes contain the domain known as DUF283 which at present has no assigned role. Using sensitive profile-profile comparisons, we detected a divergent double-stranded RNA-binding domain coinciding with the DUF283 of Dicer. This finding has potential implications regarding the mechanistic role of Dicer in RNAi.

Associate Editor: Golan Yona
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