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Bioinformatics Advance Access published online on October 2, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl496
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© 2006 The Author(s)
Received May 5, 2006
Revised August 8, 2006
Accepted September 20, 2006

Applications note

Sungear: interactive visualization and functional analysis of genomic datasets

Christopher S. Poultney 1, Rodrigo A. Gutiérrez 2, Manpreet S. Katari 3, Miriam L. Gifford 3, W. Bradford Paley 4, Gloria M. Coruzzi 3, and Dennis E. Shasha 1 *

1 Courant Institute of Mathematical Sciences, New York University, New York, USA
2 Department of Biology, New York University, New York, USA; Departamento de Genética Molecular y Microbiología, P. Universidad Católica de Chile, Santiago, Chile
3 Department of Biology, New York University, New York, USA
4 Digital Image Design Incorporated, New York, USA

* To whom correspondence should be addressed.
Dennis E. Shasha, E-mail: shasha{at}cs.nyu.edu


  Abstract

Summary: Sungear is a software system that supports a rapid, visually interactive and biologist-driven comparison of large data sets. The data sets can come from microarray experiments (e.g. genes induced in each experiment), from comparative genomics (e.g. genes present in each genome), or even from non-biological applications (e.g. demographics or baseball statistics). Sungear represents multiple data sets as vertices in a polygon. Each possible intersection among the sets is represented as a circle inside the polygon. The position of the circle is determined by the position of the vertices represented in the intersection and the area of the circle is determined by the number of elements in the intersection. Sungear shows which GO terms are over-represented in a subset of circles or anchors. The intuitive Sungear interface has enabled biologists to determine quickly which data set or groups of data sets play a role in a biological function of interest.

Availability: A live online version of Sungear can be found at http://virtualplant-prod.bio.nyu.edu/cgi-bin/sungear/index.cgi.

Supplementary information: Submitted - link TBD.

Associate Editor: Thomas Lengauer
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