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Bioinformatics Advance Access published online on October 4, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl505
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© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received August 4, 2006
Revised September 22, 2006
Accepted September 22, 2006

Applications note

TimeTree: a public knowledge-base of divergence times among organisms

S. Blair Hedges 1 *, Joel Dudley 2, and Sudhir Kumar 2

1 Department of Biology, Pennsylvania State University, University Park, PA 16802-5301, USA
2 Center for Evolutionary Functional Genomics, The Biodesign Institute and the School of Life Sciences, Arizona State University, Tempe, AZ 85287-5301, USA

* To whom correspondence should be addressed.
S. Blair Hedges, E-mail: sbh1{at}psu.edu


  Abstract

Summary: Biologists and other scientists routinely need to know times of divergence between species and to construct phylogenies calibrated to time (timetrees). Published studies reporting time estimates from molecular data have been increasing rapidly, but the data have been largely inaccessible to the greater community of scientists because of their complexity. TimeTree brings these data together in a consistent format and uses a hierarchical structure, corresponding to the tree of life, to maximize their utility. Results are presented and summarized, allowing users to quickly determine the range and robustness of time estimates and the degree of consensus from the published literature.

Availability: TimeTree is available at http://www.timetree.net

Associate Editor: Jonathan Wren
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