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Bioinformatics Advance Access published online on October 4, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl509
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© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received July 20, 2006
Revised August 13, 2006
Accepted September 29, 2006

Article

CREMOFAC - A database of chromatin remodeling factors

Agrawal Shipra 1 #,3, Kumar Chetan 1 #, and M.R.S Rao 2 *

1 Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore - 560064, India
2 Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore - 560064, India; Department of Biochemistry, Indian Institute of Science, Bangalore -560012, India

* To whom correspondence should be addressed.
M.R.S Rao, E-mail: mrsrao{at}jncasr.ac.in


  Abstract

Motivation: Chromatin remodeling is an important event in the eukaryotic nucleus rendering nucleosomal DNA accessible for various transaction processes. The dynamic nature of chromatin is facilitated by Remodeling Factors through participation of the collective action of (a) ATP and (b) Non-ATP dependent factors. Considering the importance of these factors in eukaryotes, we have developed, CREMOFAC, a dedicated and frequently updated web-database for chromatin remodeling factors.

Results: The database harbors factors from 49 different organisms reported in literature and facilitates a comprehensive search for them. In addition, it also provides in-depth information for the factors reported in the three widely studied mammals namely, human, mouse and rat. Further, information on literature, pathways, and phylogenetic relationships has also been covered. The development of CREMOFAC as a central repository for chromatin remodeling factors and the absence of such a pre-existing database heightens its utility thus making it's presence indispensable.

Availability: http://www.jncasr.ac.in/cremofac/.

#Equal contribution to this work.

3Present address: Institute of Bioinformatics and Applied Biotechnology,ITPL, Bangalore, India

Associate Editor: Dmitrij Frishman


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