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Bioinformatics Advance Access published online on October 26, 2006
Bioinformatics, doi:10.1093/bioinformatics/btl554
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© The Author (2006). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received June 6, 2006
Revised September 7, 2006
Accepted October 20, 2006

Article

Recovering metabolic pathways via optimisation

John E. Beasley 1 * and Francisco J. Planes 2

1 Mathematical Sciences, Brunel University, Uxbridge, UB8 3PH, UK
2 Mathematical Sciences, Brunel University, Uxbridge, UB8 3PH, UK; CEIT and TECNUN, University of Navarra, Manuel de Lardizabal 15, 20018 San Sebastian, Spain


  Abstract

Motivation: A metabolic pathway is a coherent set of enzyme catalysed biochemical reactions by which a living organism transforms an initial (source) compound into a final (target) compound. Some of the different metabolic pathways adopted within organisms have been experimentally determined. In this paper we show that a number of experimentally determined metabolic pathways can be recovered by a mathematical optimisation model.

Associate Editor: Alvis Brazma
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F. J. Planes and J. E. Beasley
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[Abstract] [Full Text] [PDF]


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