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Bioinformatics Advance Access published online on January 19, 2007
Bioinformatics, doi:10.1093/bioinformatics/btl644
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© The Author (2007). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Software Package for Automatic Microarray Image Analysis (MAIA)

Eugene Novikov * and Emmanuel Barillot

Service Bioinformatique, Institut Curie, 26 Rue d'Ulm, 75248 Paris Cedex 05, France.

*To whom correspondence should be addressed. Eugene Novikov, E-mail: eugene.novikov{at}curie.fr


  Abstract

Summary: Although various software solutions are currently available for microarray image analysis, one would still expect to develop algorithms ensuring higher level of intelligence and robustness. We present a fully functional software package for automatic processing of the two-color microarray images including spot localization, quantification and quality control. The developed algorithms aim at making ratio estimates more resistant to array contamination and offer automatic tools to evaluate spot quality.

Availability: A demo version of the software can be downloaded from http://bioinfo.curie.fr/projects/maia. A full version is freely available to non-commercial users upon request from the authors.

Associate Editor: Alfonso Valencia

Received on May 11, 2006; revised on December 1, 2006; accepted on December 18, 2006

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