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Bioinformatics Advance Access published online on March 7, 2007
Bioinformatics, doi:10.1093/bioinformatics/btm084
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© The Author (2007). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

EuSplice: A unified resource for the analysis of splice signals and alternative splicing in eukaryotic genes

Ashwini Bhasi 1, Ram Vinay Pandey 2, Suriya Prabha Utharasamy 2 and Periannan Senapathy 1,*

1Department of Human Genetics, Genome Technologies, Inc., 8000 Excelsior Drive, Madison, WI 53717, USA
2 Department of Bioinformatics, International Center for Advanced Genomics and Proteomics, 383 1st Cross Street, Nehru Nagar, Chennai 600096, India

*To whom correspondence should be addressed. Dr. Periannan Senapathy, E-mail: psenapathy{at}gmail.com, ps{at}genome.com


  Abstract

Motivation: Despite increased availability of genome annotation data, a comprehensive resource for in-depth analysis of splice signal distributions and alternative splicing (AS) patterns in eukaryote genomes is still lacking. To meet this need, we have developed EuSplice—a unique splice-centric database which provides reliable splice signal and AS information for 23 eukaryotes.

Results: The EuSplice database contains 95,822 AS events and 2.1 million splice signals associated with over 270,000 protein-coding genes. The intuitive, user-friendly EuSplice web interface has powerful data mining and graphics capabilities for inter-genomic comparative analysis of splice signals, putative cryptic splice sites and AS events. Moreover, the seamless integration of splicing data to extensive gene-specific annotations such as homolog annotations, functional information, mutations and sequence details makes EuSplice a powerful one-stop information resource for investigating the molecular mechanisms of complex splicing events, disease associations, and the evolution of splicing in eukaryotes.

Availability: http://66.170.16.154/EuSplice

Supplementary information: Supplementary tables and figures included

Associate Editor: Dr. Alex Bateman

Received on November 17, 2006; revised on January 20, 2007; accepted on March 1, 2007

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