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Bioinformatics Advance Access published online on May 8, 2007
Bioinformatics, doi:10.1093/bioinformatics/btm242
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© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Madeline 2.0 PDE: A new program for local and web-based pedigree drawing

Edward H. Trager 1,§, Ritu Khanna 1,§, Adrian Marrs 1,2, Lawrence Siden 3, Kari E.H. Branham 1, Anand Swaroop 1 and Julia E. Richards 1

1Department of Ophthalmology and Visual Sciences, Kellogg Eye Center (KEC), University of Michigan, Ann Arbor, Michigan 48105, USA, 2Terrain Experts, Inc. (TERREX), Tucson, Arizona 85711, USA and 3Independent Consultant, Ann Arbor, Michigan 48197, USA
§Both authors contributed equally to this paper.

To whom correspondence should be addressed. Mr. Edward Trager, E-mail: madelinesoftware{at}umich.edu


  Abstract

Summary: The Madeline 2.0 Pedigree Drawing Engine (PDE) is a pedigree drawing program for use in linkage and family-based association studies. The program is designed to handle large and complex pedigrees with an emphasis on readability and aesthetics. For complex pedigrees, we use a hybrid algorithm in which consanguinous loops are drawn as cyclic graphs whenever possible, but we resort to acyclic graphs when matings can no longer be connected without line crossings. A similar hybrid approach is used to avoid line crossings for matings between distant descendants of different founding groups. Written in object-oriented C++ and released under the GNU General Public License (GPL), Madeline 2.0 PDE reads input files specified on the command line and generates pedigree drawings without user interaction. Pedigree output in scalable vector graphics (SVG) format can be viewed in browsers with native SVG rendering support or in vector graphics editors. We provide an easy-to-use public web service, which is experimental and still under development.

Availability: http://kellogg.umich.edu/madeline

Associate Editor: Prof. Martin Bishop

Received on March 1, 2007; revised on April 10, 2007; accepted on April 29, 2007

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[Abstract] [Full Text] [PDF]


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