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Bioinformatics Advance Access published online on June 1, 2007
Bioinformatics, doi:10.1093/bioinformatics/btm295
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© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

OMA Browser – Exploring orthologous relations across 352 complete genomes

Adrian Schneider *, Christophe Dessimoz and Gaston H. Gonnet

Institute of Computational Science, Informatik, ETH Zurich, Switzerland

*To whom correspondence should be addressed. Adrian Schneider, E-mail: schneadr{at}inf.ethz.ch


  Abstract

Motivation: Inference of the evolutionary relation between proteins, in particular the identification of orthologs, is a central problem in comparative genomics. Several large-scale efforts with various methodologies and scope tackle this problem, including OMA (the Orthologous MAtrix project).

Results: Based on the results of the OMA project, we introduce here the OMA Browser, a web-based tool allowing the exploration of orthologous relations over 352 complete genomes. Orthologs can be viewed as groups across species, but also at the level of sequence pairs, allowing the distinction among one-to-one, one-to-many and many-to-many orthologs.

Availability: http://omabrowser.org

Associate Editor: Prof. Alfonso Valencia

Received on February 8, 2007; revised on May 25, 2007; accepted on May 25, 2007

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