Skip Navigation



Bioinformatics Advance Access published online on July 10, 2007
Bioinformatics, doi:10.1093/bioinformatics/btm357
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
23/18/2493    most recent
btm357v1
Right arrow Comments: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Comments are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Harbron, C.
Right arrow Articles by South, M. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harbron, C.
Right arrow Articles by South, M. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author (2007). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

RefPlus : an R package extending the RMA Algorithm

Chris Harbron 1,*, Kai-Ming Chang 2 and Marie C. South 3

1Statistical Sciences, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
2Department of Research, Koo Foundation Sun Yat-Sen Cancer Center, 125 Lihder Road, Taipei 112 Taiwan.
3Cancer Discovery Medicine, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.

*To whom correspondence should be addressed. Chris Harbron, E-mail: Chris.Harbron{at}AstraZeneca.Com


  Abstract

Summary: RMA has become a widely used methodology to pre-process Affymetrix gene expression microarrays. A limitation of RMA is that the calculated probeset intensities change when a set of microarrays is re-pre-processed after the inclusion of additional microarrays into the analysis set. Here we report the availability of the RefPlus package containing functions to perform the Extrapolation Strategy and Extrapolation Averaging algorithms which address these issues.

Availability: The software is implemented in the R language and can be downloaded from the Bioconductor project (http://www.bioconductor.org).

Contact: Chris.Harbron{at}AstraZeneca.Com

Supplementary information: Further details of the workings and evaluation of these functions are given in the documentation available on the Bioconductor website.

Associate Editor: Prof. David Rocke

Received on May 25, 2007; revised on June 25, 2007; accepted on July 4, 2007

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.