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Bioinformatics Advance Access published online on July 28, 2007
Bioinformatics, doi:10.1093/bioinformatics/btm383
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© The Author (2007). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Flavitrack: An annotated database of flavivirus sequences

Milind Misra 1,{dagger} and Catherine H. Schein 1,2,3,*

Departments of 1Biochemistry and Molecular Biology and 2Microbiology and Immunology, Sealy Center for Structural Biology and Molecular Biophysics, 3Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas, 77555-0857

*To whom correspondence should be addressed. Catherine H. Schein, E-mail: chschein{at}utmb.edu


  Abstract

Motivation: Properly annotated sequence data for flaviviruses, which cause diseases such as tick-borne encephalitis (TBE), dengue fever (DF), West Nile (WN), and yellow fever (YF), can aid in the design of antiviral drugs and vaccines to prevent their spread. Flavitrack was designed to help identify conserved sequence motifs, interpret mutational and structural data, and track evolution of phenotypic properties.

Summary: Flavitrack contains over 590 complete flavivirus genome/protein sequences and information on known mutations and literature references. Each sequence has been manually annotated according to its date and place of isolation, phenotype, and lethality. Internal tools are provided to rapidly determine relationships between viruses in Flavitrack and sequences provided by the user.

Availability: http://carnot.utmb.edu/flavitrack

Contact: chschein{at}utmb.edu

Supplementary Data: http://carnot.utmb.edu/flavitrack/B1S1.html

{dagger} Present address: Computational Biosciences Department, Sandia National Laboratories, PO Box 5800 MS-1413, Albuquerque, NM 87185-1413.

Associate Editor: Dr. Jonathan Wren

Received on April 4, 2007; revised on June 22, 2007; accepted on July 10, 2007

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