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Bioinformatics Advance Access published online on September 14, 2007
Bioinformatics, doi:10.1093/bioinformatics/btm459
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© The Author (2007). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

EGEETomo: A user-friendly, fault-tolerant and grid-enabled application for 3D reconstruction in electron tomography

J.R. Bilbao-Castro , I. García and J.J. Fernández *

Dept. Computer Architecture and Electronics, University of Almería, 04120 Almería, Spain.

*To whom correspondence should be addressed. Prof. Jose-Jesus Fernández, E-mail: jose{at}ace.ual.es, jjfdez{at}yal.es


  Abstract

Summary: Electron tomography is the leading technique to elucidate the structure of complex biological specimens. Due to the resolution needs, huge reconstructions are required. Grid computing has the potential to face the significant computational demands involved. However, there are a number of key issues, such as stability or difficult user-grid interaction, that currently preclude fully exploitation of its potential. EGEETomo is a user-friendly application that facilitates the interaction with the grid for the non-specialized user and automates job submission and supervision. In addition, EGEETomo is supplied with an automated fault recovery mechanism, which is key to make all the work transparent to the user. EGEETomo significantly accelerates tomographic reconstruction by exploiting the computational resources in the EGEE grid with minimal user intervention

Availability: http://www.ace.ual.es/~jrbcast/EGEETomo.tar.gz

Contact: jrbcast{at}ace.ual.es, jose{at}ace.ual.es

Associate Editor: Prof. Anna Tramontano

Received on June 28, 2007; revised on August 16, 2007; accepted on September 3, 2007

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