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Bioinformatics Advance Access published online on January 2, 2008
Bioinformatics, doi:10.1093/bioinformatics/btm630
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© The Author (2008). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

NetworkBLAST: Comparative analysis of protein networks

Maxim Kalaev 1,*, Mike Smoot 2, Trey Ideker 2 and Roded Sharan 1,*

1 School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel.
2 Dept. of Bioengineering, UC San Diego, La Jolla, CA 92093, USA

*To whom correspondence should be addressed. Maxim Kalaev, E-mail: kalaevma{at}post.tau.ac.il, Roded Sharan, roded{at}post.tau.ac.il


  Abstract

Summary: The identification of protein complexes is a fundamental challenge in interpreting protein-protein interaction data. Cross-species analysis allows coping with the high levels of noise that are typical to these data. The NetworkBLAST web-server provides a platform for identifying protein complexes in protein-protein interaction networks. It can analyze a single network or two networks from different species. In the latter case, NetworkBLAST outputs a set of putative complexes that are evolutionarily conserved across the two networks.

Availability: NetworkBLAST is available as web-server at: www.cs.tau.ac.il/~roded/networkblast.htm.

Contact: kalaevma{at}post.tau.ac.il, roded{at}post.tau.ac.il

Associate Editor: Dr. Limsoon Wong

Received on July 22, 2007; revised on October 27, 2007; accepted on December 18, 2007

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