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Bioinformatics Advance Access published online on January 18, 2008
Bioinformatics, doi:10.1093/bioinformatics/btn007
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© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

BEN: A novel domain in chromatin factors and DNA viral proteins

Saraswathi Abhiman , Lakshminarayan M. Iyer and L. Aravind *

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA

*To whom correspondence should be addressed. Dr. L. Aravind, E-mail: aravind{at}ncbi.nlm.nih.gov


  Abstract

We report a previously uncharacterized {alpha}-helical module, the BEN domain, in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Contextual analysis suggests that the BEN domain mediates pro-tein-DNA and protein-protein interactions during chromatin organiza-tion and transcription. The presence of BEN domains in a poxviral early virosomal protein and in polydnaviral proteins also suggests a possible role for them in organization of viral DNA during replication or transcription.

Associate Editor: Dr. Alex Bateman

Received on November 20, 2007; revised on November 20, 2007; accepted on January 2, 2008

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