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Bioinformatics Advance Access published online on February 21, 2008
Bioinformatics, doi:10.1093/bioinformatics/btn068
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© The Author (2008). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

GOTreePlus: An Interactive Gene Ontology Browser for Proteomics Projects

Bongshin Lee 1, Kristy Brown 2, Yetrib Hathout 2 and Jinwook Seo 2,*

1Microsoft Research, One Microsoft Way, Redmond, WA 98052 USA
2Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010 USA

*To whom correspondence should be addressed. Prof. Jinwook Seo, E-mail: jseo{at}cnmcresearch.org


  Abstract

Summary: We developed an interactive GO (gene ontology) browser named GOTreePlus that superimposes annotation information over GO structures. GOTreePlus It can facilitate the identification of important GO terms through interactive visualization of them in the GO structure. The interactive pie chart summarizing an annotation distribution for a selected GO term provides users with a succinct context-sensitive overview of their experimental results. We tested our GOTreePlus tool using a proteome profiling dataset obtained on differentiation of retinal pigment epithelial cells where 399 proteins were quantified.

Availability: http://bioinformatics.cnmcresearch.org/GOTreePlus/

Contact: bongshin{at}microsoft.com or jseo{at}cnmcresearch.org

Associate Editor: Prof John Quackenbush

Received on December 13, 2007; revised on January 31, 2008; accepted on February 17, 2008

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