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Bioinformatics Advance Access published online on March 5, 2008
Bioinformatics, doi:10.1093/bioinformatics/btn076
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© The Author (2008). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

BicOverlapper: A tool for bicluster visualisation

Rodrigo Santamaría 1,*, Roberto Therón 1,{dagger} and Luis Quintales 1

1Departamento de Informática y Automática, Pz. de Los Caídos S/N, 37008 Salamanca, Spain

*To whom correspondence should be addressed. Rodrigo Santamaría, E-mail: rodri{at}usal.es


  Abstract

Motivation: BicOverlapper is a tool to visualise biclusters from gene expression matrices in a way that helps to compare biclustering methods, to unravel trends and to highlight relevant genes and conditions. A visual approach can complement biological and statistical analysis and reduce the time spent by specialists interpreting the results of biclustering algorithms. The technique is based on a force-directed graph where biclusters are represented as flexible overlapped groups of genes and conditions.

Availability: The BicOverlapper software and supplementary material are available at http://vis.usal.es/bicoverlapper.

Contact: rodri{at}usal.es

Associate Editor: Prof. John Quackenbush

{dagger} the first two authors should be reported as joint First Authors

Received on December 17, 2007; revised on February 9, 2008; accepted on February 24, 2008

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