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Bioinformatics Advance Access published online on May 22, 2008
Bioinformatics, doi:10.1093/bioinformatics/btn238
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© The Author (2008). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

A Bayesian Estimator of Protein-Protein Association Probabilities

JM Gilmore 1, DL Auberry 1, JL Sharp 2, AM White 1, KK Anderson 1 and DS Daly 1,*

1Pacific Northwest National Laboratory, Battelle Boulevard, Richland WA, 99352
2Department of Applied Economics and Statistics, Clemson University, Clemson, SC, 29634

*To whom correspondence should be addressed. DS Daly, E-mail: ds.daly{at}pnl.gov


  Abstract

Summary: The Bayesian Estimator of Protein-Protein Association Probabilities (BEPro3) is a software tool for estimating probabilities of protein-protein association between bait and prey protein pairs using data from multiple-bait, multiple-replicate, protein LC-MS/MS affinity isolation experiments.

Availability: BEPro3 is public domain software, has been tested on Windows XP and version 10.4 or newer of the Mac OS 10.4, and is freely available from http://www.pnl.gov/statistics/BEPro3.

Contact: ds.daly{at}pnl.gov

Supplementary Information: A user guide, example dataset with analysis and additional documentation are included with the BEPro3 download

Associate Editor: Prof. Burkhard Rost

Received on October 8, 2007; revised on May 15, 2008; accepted on May 15, 2008

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