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Bioinformatics Advance Access published online on July 25, 2008
Bioinformatics, doi:10.1093/bioinformatics/btn388
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© The Author (2008). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

dbNEI2.0: building multilayer network for drug-NEI-disease

Jing Zhang , Tao Ma , Yanda Li and Shao Li *

MOE Key Laboratory of Bioinformatics and Bioinformatics Div, TNLIST / Department of Automation, Tsinghua University, Beijing 100084, China

*To whom correspondence should be addressed. Prof. Shao Li, E-mail: shaoli{at}mail.tsinghua.edu.cn


  Abstract

Summary: The neuro-endocrine-immune (NEI) system plays a critical regulatory role in modulating host homeostasis and optimizing health. We created the dbNEI two years ago to collect NEI mole-cules and interactions. For transferring the conceptual NEI to the systematic NEI network and uncovering the NEI's medical function, we updated the dbNEI2.0 in three ways: 1) extended NEI molecules to 2242 genes and 7657 chemical compounds by using GO-based data mining strategy, 2) added multilayer interactions of NEI mole-cules including KEGG signal transduction and metabolic pathways, HPRD protein-protein interactions, transcription factor and mi-croRNA regulations, and 3) connected 611 drugs and 823 diseases through multilayer NEI interactions. The reconstructed drug-NEI-disease network will facilitate the systematic study of NEI system.

Availability: http://bioinfo.au.tsinghua.edu.cn/dbNEIweb/.

Contact: shaoli{at}mail.tsinghua.edu.cn

Supplementary information: More descriptions and statistical analyses about dbNEI2.0 can be found on the website.

Associate Editor: Prof. Dmitrij Frishman

Received on April 9, 2008; revised on July 14, 2008; accepted on July 24, 2008

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