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Bioinformatics Advance Access published online on July 28, 2008
Bioinformatics, doi:10.1093/bioinformatics/btn392
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© The Author (2008). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

HELIQUEST: a web server to screen sequences with specific {alpha} -helical properties

Romain Gautier *, Dominique Douguet , Bruno Antonny and Guillaume Drin

Université de Nice Sophia Antipolis and CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, 660 route des Lucioles, 06560 Valbonne.

*To whom correspondence should be addressed. Dr. Romain Gautier, E-mail: gautier{at}ipmc.cnrs.fr


  Abstract

Summary: HELIQUEST calculates the physicochemical properties and amino acid composition of an {alpha} -helix and screens databank to identify protein segments possessing similar features. This server is also dedicated to mutating helices manually or automatically by genetic algorithm to design analogues of defined features.

Availability: http://heliquest.ipmc.cnrs.fr

Contact: gautier{at}ipmc.cnrs.fr

Supplementary information: http://heliquest.ipmc.cnrs.fr/HelpProcedure.htm

Associate Editor: Prof. Anna Tramontano

Received on April 17, 2008; revised on July 16, 2008; accepted on July 25, 2008

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