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Bioinformatics Advance Access published online on August 14, 2008
Bioinformatics, doi:10.1093/bioinformatics/btn431
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© The Author (2008). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes.

Antonina Andreeva 1,* and Henning Tidow 1

1MRC Centre for Protein Engineering, Cambridge CB2 0QH, UK

*To whom correspondence should be addressed. Dr. Antonina Andreeva, E-mail: tony{at}mrc-lmb.cam.ac.uk


  Abstract

Summary: We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyltransferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as RNA recognition and binding module.

Contact: tony{at}mrc-lmb.cam.ac.uk

Supplementary information: Supplementary data are available on Bioinformatics online

Associate Editor: Prof. Ivo Hofacker

Received on May 21, 2008; revised on August 12, 2008; accepted on August 13, 2008

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