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Bioinformatics Advance Access published online on August 19, 2008
Bioinformatics, doi:10.1093/bioinformatics/btn439
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© The Author (2008). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

ITFP: an integrated platform of mammalian transcription factors

Guangyong Zheng 1,2,3, Kang Tu 3,6, Qing Yang 2, Yun Xiong 2, Chaochun Wei 4,5, Lu Xie 5, Yangyong Zhu 2,5,* and Yixue Li 3,5,*

1School of Life Sciences, Fudan University, Shanghai 200433, China, 2Department of Computing and Information Technol-ogy, Fudan University, Shanghai 200433, China, 3Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, 4College of Life Sciences and Technology, Shanghai Jiaotong University, Shanghai 200240, China, 5Shanghai Center for Bioinformation Technology, Shanghai 200235, China, 6Graduate School of the Chinese Academy of Sciences, Beijing 100039, China

*To whom correspondence should be addressed. Yangyong Zhu, E-mail: yyzhu{at}fudan.edu.cn, Yixue Li. E-mail: yxli{at}sibs.ac.cn


  Abstract

Summary: Investigation of transcription factors (TFs) and their downstream regulated genes (targets) is a significant issue in post genome era, which can provide a brand new vision for some vital biological process. However, information of TFs and their targets in mammalian is far from sufficient. Here, we developed an integrated transcription factor platform (ITFP), which included abundant TFs and their targets of mammalian. In current release, ITFP includes 4105 putative TFs and 69496 potential TF-target pairs for human, 3134 putative TFs and 37040 potential TF-target pairs for mouse, and 1114 putative TFs and 18055 potential TF-target pairs for rat. In short, ITFP will serve as an important resource for the research community of transcription and provide strong support for regulatory network study.

Availability: ITFP can be accessed at http://itfp.biosino.org/itfp

Contact: yyzhu@fudan.edu.cn, yxli@sibs.ac.cn

Associate Editor: Prof. Dmitrij Frishman

Received on May 10, 2008; revised on July 10, 2008; accepted on August 17, 2008

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