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Bioinformatics Advance Access published online on August 21, 2008
Bioinformatics, doi:10.1093/bioinformatics/btn449
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© The Author (2008). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

AMIN domains have a predicted role in localization of diverse periplasmic protein complexes

Robson Francisco de Souza 1,4, Vivek Anantharaman 3,4, Sandro José de Souza 2, L. Aravind 3,* and Frederico J. Gueiros-Filho 1,*

1Departamento de Bioquímica, Universidade de São Paulo, São Paulo, Brazil; 2Ludwig Institute for Cancer Research, São Paulo Branch, São Paulo, Brazil; 3 National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA

*To whom correspondence should be addressed. Dr. Frederico J. Gueiros-Filho, E-mail: fgueiros{at}iq.usp.br


  Abstract

We describe AMIN (AmiC N-terminal region), a novel protein domain found specifically in bacterial periplasmic proteins. AMIN domains are widely distributed among peptidoglycan hydrolases and transporter protein families. Based on experimental data, contextual information and phyletic profiles we suggest that AMIN domains mediate the targeting of periplasmic or extracellular proteins to specific regions of the bacterial envelope.

4These authors contributed equally to this work

Associate Editor: Prof. Dmitrij Frishman

Received on March 29, 2008; revised on August 8, 2008; accepted on August 19, 2008

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