Skip Navigation



Bioinformatics Advance Access published online on September 30, 2008
Bioinformatics, doi:10.1093/bioinformatics/btn510
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrowOA All Versions of this Article:
24/23/2782    most recent
btn510v2
btn510v1
Right arrow Comments: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Comments are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Heymann, M.
Right arrow Articles by Deléage, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Heymann, M.
Right arrow Articles by Deléage, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2008 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

MSX-3D : A tool to validate 3D protein models using mass spectrometry

Michaël Heymann 1, David Paramelle 2, Gilles Subra 2, Eric Forest 3, Jean Martinez 2, Christophe Geourjon 1 and Gilbert Deléage 1,*

1Institut de Biologie et Chimie des Protéines (IBCP) UMR5086 CNRS, Université Lyon 1, IFR128 BioSciences Lyon-Gerland, 7 passage du Vercors 69367 Lyon cedex 07, France
2Institut des Biomolécules Max Mousseron (IBMM), UMR5247 CNRS, Universités Montpellier 1 et 2, 15 avenue Charles Flahault, 34000 Montpellier, France
3Protein Mass Spectrometry Laboratory, Institut de Biologie Structurale, UMR5075 CEA, CNRS, UJF, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France

*To whom correspondence should be addressed. Prof. Gilbert Deléage, E-mail: g.deleage{at}ibcp.fr


  Abstract

Motivation: The technique of chemical cross-linking followed by mass spectrometry has proven to bring valuable information about the protein structure and interactions between proteic subunits. It is an effective and efficient way to experimentally investigate some aspects of a protein structure when NMR and X-ray crystallography data are lacking.

Results: We introduce MSX-3D, a tool specifically geared to validate protein models using mass spectrometry. In addition to classical peptides identifications, it allows an interactive 3D visualization of the distance constraints derived from a cross-linking experiment.

Availability: Freely available at http://proteomics-pbil.ibcp.fr

Contact: g.deleage{at}ibcp.fr

Associate Editor: Prof. Anna Tramontano

Received on May 26, 2008; revised on August 28, 2008; accepted on September 27, 2008

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.