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Bioinformatics Advance Access published online on October 9, 2008
Bioinformatics, doi:10.1093/bioinformatics/btn531
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© The Author (2008). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

FABSIM: a software for generating FST distributions with various ascertainment biases

Anna Ramírez-Soriano 1 and Francesc Calafell 1,2,*

1 IBE, Institute of Evolutionary Biology (UPF-CSIC), CEXS-UPF-PRBB. Doctor Aiguader, 88. 08003 Barcelona, Catalonia, Spain.
2 CIBER en Epidemiologia y Salud Pública (CIBEREsp), Spain.

*To whom correspondence should be addressed. Mrs. Anna Ramírez-Soriano, E-mail: anna.ramirez{at}upf.edu


  Abstract

Summary: We have developed a software that applies ascertainment bias on simulated DNA sequences and calculates FST on them, so they can be used to generate neutral distributions that are appropriate to test whether the genetic differentiation of a particular gene between populations is compatible with neutral evolution, or, on the contrary, suggests local adaptation by natural selection.

Availability: FABSIM is available from http://www.snpator.com/public/downloads/aRamirez/FABSIM/.

Contact: Correspondence should be addressed to francesc.calafell{at}upf.edu.

Supplementary information: Supplementary information and fig-ures can be dowloaded from the journal's web site. The data from which figures are built can be dowloaded from http://www.snpator.com/public/downloads/aRamirez/.

Associate Editor: Prof. Martin Bishop

Received on September 5, 2008; revised on October 7, 2008; accepted on October 7, 2008

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