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Bioinformatics Advance Access published online on November 9, 2008
Bioinformatics, doi:10.1093/bioinformatics/btn581
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© The Author (2008). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Genetic association analysis with FAMHAP: a major program update

Christine Herold 1 and Tim Becker 1

1Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany

To whom correspondence should be addressed. Christine Herold, E-mail: herold{at}imbie.meb.uni-bonn.de


  Abstract

Summary: FAMHAP is an established software for haplotype association analysis of nuclear families. We have released a major update that comprises various new features for case-control data. Furthermore, we provide an additional program runFamhap that allows users to start the same method repeatedly for varying sets of genetic markers. In addition, a platform-independent graphical user interface (GUI) was developed to simplify the usage of both FAMHAP and runFamhap. The runFamhap program greatly facilitates the application of FAMHAP to genome-wide association studies (GWAS) and supports flexible genome-wide haplotype analysis. As an example, we describe application to HapMap data.

Availability: The software is available at http://famhap.meb.uni-bonn.de

Contact: herold{at}imbie.meb.uni-bonn.de; becker{at}imbie.meb.uni-bonn.de

Associate Editor: Dr. Alex Bateman

Received on August 18, 2008; revised on October 29, 2008; accepted on November 6, 2008

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