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Bioinformatics Advance Access published online on February 20, 2009
Bioinformatics, doi:10.1093/bioinformatics/btp096
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©2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Seevolution: visualizing chromosome evolution

Andrés Esteban-Marcos 1, Aaron E. Darling 1,* and Mark A. Ragan 1

1Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, 4072, Australia

*To whom correspondence should be addressed. Dr. Aaron Darling, E-mail: aarondarling{at}ucdavis.edu


  Abstract

Summary: Genome evolution underpins all of biology, yet its principles can be difficult to communicate to the non-specialist. To facilitate broader understanding of genome evolution, we have designed an interactive 3D environment that enables visualization of diverse genome evolution processes. The system can intuitively and interactively animate mutation histories involving genome rearrangement, point mutation, recombination, insertion, and deletion. Multiple organisms related by a phylogeny can be visualized simultaneously. As methods to infer evolutionary histories of genomes become increasingly complex, visualization of the evolutionary process will not only be useful for communication, but will also serve as an exploratory tool for discovering new patterns of genome evolution.

Availability: The software is licensed under the GNU GPL and available for download from http://seevolution.org.

Contact: aarondarling{at}ucdavis.edu

Associate Editor: Prof. John Quackenbush

Received on August 5, 2008; revised on January 30, 2009; accepted on February 16, 2009

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