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Bioinformatics Advance Access published online on February 27, 2009
Bioinformatics, doi:10.1093/bioinformatics/btp116
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© The Author (2009). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

WSsas: a web service for the annotation of functional residues through structural homologues

David Talavera 1,*,#, Roman A Laskowski 1 and Janet M Thornton 1

1EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD.

*To whom correspondence should be addressed. David Talavera, E-mail: talavera{at}ebi.ac.uk


  Abstract

Motivation: Annotation tools help scientists to traverse the gap between characterised and uncharacterised proteins. Tools for the prediction of protein function include those which predict the function of entire proteins or complexes, those annotating functional domains and those which predict specific residues within the domain. We have developed WSsas, a web service focused on the annotation of essential functional residues. WSsas uses similarity searches and pairwise alignments to transfer functional information about binding, catalytic and protein-protein interaction residues from solved structures to query sequences. In addition, WSsas can supply information about the relevant functional atoms. The web service definition (WSDL) file and a Perl client are freely available at http://www.ebi.ac.uk/thornton-srv/databases/WSsas/.

Associate Editor: Prof. Burkhard Rost

#Present address: Faculty of Life Sciences, University of Manchester, Manchester, M20 6AD.

Received on November 24, 2008; revised on February 9, 2009; accepted on February 23, 2009

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