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Bioinformatics Advance Access published online on March 4, 2009
Bioinformatics, doi:10.1093/bioinformatics/btp121
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© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

A web-server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype.

Igor B. Kuznetsov *, Michael McDuffie and Roxana Moslehi *

Gen*NY*Sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, University at Albany, One Discovery Drive, Rensselaer, NY 12144

*To whom correspondence should be addressed. Prof. Igor Kuznetsov and Roxana Moslehi, E-mail: IKuznetsov{at}albany.edu RMoslehi{at}albany.edu


  Abstract

Summary: NAT2 is an important enzyme that catalyzes the acetylation of aromatic and heterocyclic amine carcinogens. Individuals in human populations are divided into three NAT2 acetylator phenotypes: slow, rapid, and intermediate. NAT2PRED is a web-server that implements a supervised pattern recognition method to infer NAT2 phenotype from SNPs found in NAT2 gene positions 282, 341, 481, 590, 803, and 857. The web-server can be used for a fast determination of NAT2 phenotypes in genetic screens.

Availability: Freely available at http://nat2pred.rit.albany.edu

Contact: IKuznetsov{at}albany.edu; RMoslehi{at}albany.edu

Associate Editor: Prof. Alfonso Valencia

Received on November 26, 2008; revised on February 5, 2009; accepted on February 26, 2009

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