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Bioinformatics Advance Access published online on March 17, 2009
Bioinformatics, doi:10.1093/bioinformatics/btp159
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© 2009 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Synergy Disequilibrium Plots: graphical visualization of pairwise synergies and redundancies of SNPs with respect to a phenotype

John Watkinson and Dimitris Anastassiou *

Center for Computational Biology and Bioinformatics and Department of Electrical Engineering, Columbia University, 500 West 120th Street, New York, NY 10027, USA

*To whom correspondence should be addressed. Prof. Dimitris Anastassiou, E-mail: anastas{at}ee.columbia.edu


  Abstract

Summary: We present a visualization tool applied on genome-wide association data, revealing disease-associated haplotypes, epistati-cally interacting loci, as well as providing visual signatures of multi-variate correlations of genetic markers with respect to a phenotype.

Availability: Freely available on the web at: http://www.ee.columbia.edu/~anastas/sdplots

Contact: anastas{at}ee.columbia.edu

Supplementary Information: Supplementary data are available at Bioinformatics online.

Associate Editor: Prof. Martin Bishop

Received on February 9, 2009; revised on March 7, 2009; accepted on March 15, 2009

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